Muscle blood flow, hypoxia, and hypoperfusion

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Muscle blood flow, hypoxia, and hypoperfusion.

Blood flow increases to exercising skeletal muscle, and this increase is driven primarily by vasodilation in the contracting muscles. When oxygen delivery to the contracting muscles is altered by changes in arterial oxygen content, the magnitude of the vasodilator response to exercise changes. It is augmented during hypoxia and blunted during hyperoxia. Because the magnitude of the increased va...

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HIGHLIGHTED TOPIC Hypoxia Muscle blood flow, hypoxia, and hypoperfusion

Joyner MJ, Casey DP. Muscle blood flow, hypoxia, and hypoperfusion. J Appl Physiol 116: 852– 857, 2014. First published July 25, 2013; doi:10.1152/japplphysiol.00620.2013.—Blood flow increases to exercising skeletal muscle, and this increase is driven primarily by vasodilation in the contracting muscles. When oxygen delivery to the contracting muscles is altered by changes in arterial oxygen co...

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Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans.

We evaluated the contribution of changes in systemic arterial pressure and local vasodilation to blood flow restoration in contracting human muscles during acute hypoperfusion. Healthy subjects (n=10) performed rhythmic forearm exercise (10% and 20% of maximum) while a balloon in the brachial artery located above the elbow was inflated. Each trial included 3 min of rest, exercise, exercise with...

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EFFECTS OF HYPOXIC HYPOXIA AND CARBON MONOXIDE-INDUCED HYPOXIA ON THE CARDIOVASCULAR SYSTEM AND REGIONAL BLOOD FLOW OF THE ANESTHETIZED CAT

The purpose of this study was to investigate the potential responses of the cardiovascular system and regional blood flow to hypoxic hypoxia (BB) and to carbon monoxide (CO)-induced hypoxia (COH). Ten anesthetized cats were studied under two nonnoxic (control: CONT) and two hypoxic conditions. Four types of radioactive micro spheres were used to measure regional blood flow during CONT an...

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Blood flow, not hypoxia, determines intramucosal PCO2

Monitoring tissue hypoxia in critically ill patients is a challenging task. Tissue PCO2 has long been proposed as a marker of tissue hypoxia, although there is considerable controversy on whether the rise in CO2 with hypoxia is caused by anaerobic metabolism and excess CO2 production or by the accumulation of aerobically produced CO2 in the setting of blood flow stagnation. The prevention of in...

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ژورنال

عنوان ژورنال: Journal of Applied Physiology

سال: 2014

ISSN: 8750-7587,1522-1601

DOI: 10.1152/japplphysiol.00620.2013